A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.
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چکیده
منابع مشابه
The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.
A cDNA clone isolated from rat liver was demonstrated to encode a soluble, secreted growth hormone (GH)-binding protein consistent with the properties of the newly discovered serum GH-binding protein. The protein coding region of this cDNA was identical in sequence to the extracellular domain of the rat liver GH receptor up to three amino acids before the putative transmembrane domain. At this ...
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The epidermal growth factor receptor (EGFR) is encoded by the c-erbB1 proto-oncogene and plays an important role in the control of cell growth and differentiation. To study the potential growth regulatory role of soluble EGF receptors, we have isolated cDNA clones encoding a truncated, secreted form of the human EGFR. The 5' sequence of this cDNA is identical to the EGFR transcript encoding the...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1990
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.10.6.2973